Tuesday 1-13-15

Tuesday 1-13-15

THURSDAY 2-12-15 LEARNING OBJECTIVE: WHAT ARE GENES? ENTRY TASK: WHAT DO YOU KNOW ABOUT: GENES DNA GENE THERAPY

CANCER CYSTIC FIBROSIS PROTEIN HOW ARE THESE TERMS RELATED? PLAN OF THE DAY INTRO TO GENETICS DNA AND CELL DIVISION UNIT

10 YEARS OF GENOME RESEARCH AND GENETIC DISEASES HTTPS://WWW.YOUTUBE.COM/WATCH?V=FGQ-XOYORWY 60:00 FRIDAY 2-13-15 LEARNING OBJECTIVE: STRUCTURE OF THE DNA MOLECULE

ENTRY TASK: WHAT ARE THE FOUR BASES PRESENT IN THE DNA MOLECULE? LOOK AT PAGE 345 FIGURE 12-5 AND TRANSFER THE DIAGRAM TO YOUR JOURNAL 1ST ELODEA 4TH HEARTS PLAN OF THE DAY

CHECK YOUR TEST RESULTS FOR CHAPS. 8 & 9 INTRO TO GENETICS DNA AND CELL DIVISION UNIT 10 YEARS OF GENOME RESEARCH AND GENETIC DISEASES HTTPS://WWW.YOUTUBE.COM/WATCH?V=FGQ-XOYORWY 60:00 TUESDAY 2-17-15

LEARNING OBJECTIVE: STRUCTURE OF THE DNA MOLECULE ENTRY TASK: WHAT WOULD BE THE MATCHING DNA STRAND THAT WOULD PAIR WITH THIS SEQUENCE OF BASES? ATAATTGCGGATTC

PLAN OF THE DAY DNA STRUCTURE AND FUNCTION CRASH COURSE ON DNA BRAINSTORM WITH PARTNER ON WHAT MATERIALS TO BRING FOR DNA MODEL HTTPS://WWW.YOUTUBE.COM/WATCH?V=RW7XU7DURG4 53:00 HTTPS://WWW.GOOGLE.COM/?GWS_RD=SSL#Q=DNA+CRASH+COURSE 13:00 HTTPS://WWW.YOUTUBE.COM/WATCH?V=5QSRMEIWSUC

8:00 REPLICATION WITH THE AMOEBA SISTERS The basic unit of the DNA molecule is called: NUCLEOTIDE A NUCLEOTIDE in DNA has three parts: A ring-shaped sugar called deoxyribose A phosphate group

A nitrogenous base (single or double ring of carbon and nitrogen atoms) Nucleotide monomers join together by covalent bonds between the sugar of one nucleotide and the phosphate of the next,

forming a sugarphosphate backbone. Nitrogenous Bases The bases pair up (A-T & G-C) forming the DOUBLE HELIX first described by Watson and Crick

Watson, Crick and Franklin Various ways to model DNA structure http://www.umass.edu/molvis/tutorials/dna/dnapairs.htm

manipulate DNA WEDNESDAY 2-18-15 LEARNING OBJECTIVE: STRUCTURE OF THE DNA MOLECULE ENTRY TASK: DNA GOES THROUGH THE PROCESS OF REPLICATION (DUPLICATION) IN OUR CELLS.

WHY DO YOU THINK THIS PROCESS IS NECESSARY? PLAN OF THE DAY WORK WITH YOURSELF OR WITH YOUR PARTNER TO BUILD YOUR 3D DNA MODEL IF YOU DID NOT BRING MATERIALS FOR YOUR OWN MODEL, GET THE HANDOUT TO DO THE FLAT DNA MODEL

IF FINISHED, READ AND TAKE NOTES OF SECTION 12.3 (PP 350-351) IN YOUR NOTEBOOK (DUE FRIDAY 19) DNA MODELS PAPER MODELS HTTP://WWW.GOV.MB.CA/CONSERVATION/SUSTAIN/DNADONE.PDF HTTP://WWW.MYSCIENCEBOX.ORG/BOOK/EXPORT/HTML/347 HTTP://

WWW.ALDER.K12.OH.US/USERFILES/251/CLASSES/2831/DNAMODELPARTSFORYOURPRESE NTATION.PDF ORIGAMI DNA HTTPS://WWW.YOUTUBE.COM/WATCH?V=LEJF0F1JTUQ HTTP://WWW.DNAI.ORG/TEACHERGUIDE/GUIDE.HTML HTTP://WWW.DNAI.ORG/TEACHERGUIDE/PDF/ORI_COLOR.PDF HTTP://WWW.DNAI.ORG/TEACHERGUIDE/PDF/ORIGAMI_INST.PDF HTTP://WWW.DNAI.ORG/TEACHERGUIDE/PDF/ORI_BW.PDF

THURSDAY 2-19-15 LEARNING OBJECTIVE: STRUCTURE OF THE DNA MOLECULE ENTRY TASK: GET YOUR DNA MODELS READY. IN 20 MINUTES WE WILL START PRESENTATIONS PLAN OF THE DAY

FINISH LAST TOUCHES OF YOUR DNA MODEL AND PRESENT IT TO YOUR CLASSMATES IF FINISHED, READ AND TAKE NOTES OF SECTION 12.3 (PP 350-351) IN YOUR NOTEBOOK (DUE FRIDAY 20) FRIDAY 2-20-15 LEARNING OBJECTIVE: DNA REPLICATION PROCESS

ENTRY TASK: NAME TWO OF THE ENZYMES INVOLVED IN THE DNA REPLICATION PROCESS AND THEIR FUNCTION PLAN OF THE DAY LAST PRESENTATIONS OF DNA MODEL REPLICATION NOTES

REPLICATION PRACTICE WITH WHITE BOARD CREATING A DNA REPLICATION SKIT WITH THE ENTIRE CLASS Why does DNA need to be replicated? Growth new cells - reproduction How does this process

happen? REPLICATION IN 3 STEPS DNA replication results in two new DNA molecules, each

containing one new strand (yellow) and one original strand (blue) Weak bonds Hydrogen bonds

Comes apart easily Comes together easily Overview of DNA replication DNA separates Complementary

nucleotides are linked along separated strands initiate Initiator protein guides unzipper protein

(helicase) to correct position on DNA untwister Untwister (topoisomerase) unwinds the DNA double

helix in advance of the unzipper unzip Unzipper separates DNA strands, breaking weak bonds

between the nucleotides assemble Builders (polymerases) assemble new DNA strand by joining

nucleotides to their matching complements on the exposed strands straightners Straighteners (single-strand

DNA binding proteins) keep single strand of DNA from tangling Phosphate provides energy Phosphate bond

energy from the new nucleotides is used to make the new bonds Leading vs. Lagging strand Leading (top) strand is built

continuously as the builder follows behind the unzipper, but the Lagging (lower) strand builds in the opposite direction

Lagging strand Lagging (lower) builder makes a loop with the DNA strand and builds in

opposite direction Lagging strand Built in small sections Sections linked by enzyme ligase

Repairs of DNA Erasers (Repair Nuclease): find poorly matched or damaged nucleotides and cut them out

Repairs of DNA Builders (Polymerase): fill gaps using other DNA strand as a guide Repairs of DNA

Stitchers (Ligase): uses ATP to restore continuity of backbone of repaired strand Big picture of DNA replication

Replication review REPLICATION IN 3 STEPS DNA replication results in two DNA molecules,

each with one new strand (yellow) and one old strand (blue) DNA replication

animations http://www.youtube.com/watch?v=4jtmO ZaIvS0 http://www.youtube.com/watch?v=gW3qZ F9cLIA http://www.youtube.com/watch?v=oNW_ ykH3AvA http:// www.youtube.com/watch?v=hC_8y8fNkC

w TED talk DNA replication Chromosomes- malaria http://www.youtube.com/watch?v=dMPX u6GF18M Timing of replication article: http:// hms.harvard.edu/news/marching-our-ow

n-sequences

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