Target agent: VX

Target agent: VX

Target agent: VX CH3 O O P H3C S CH3 N CH3 O H3C N O CH3 acetylcholine CH3 VX CH3 CH3 Other chemical agents: O O H3C P F CH3 CH3 O H3C P CH3 sarin O CH3 F CH3 soman H3C P CH3 O P S O

O parathion NO2 O P N CN tabun Pesticides: S CH3 O O S CO2Et CO2Et malathion CH3 Target agent: VX O O P H3C S VX CH3 N CH3 O CH3 H3C CH3 CH3 Acetylcholinesterase O N CH3 CH3 acetylcholine Organophosphorus Compounds Other chemical agents: O

O H3C P F CH3 CH3 O H3C P CH3 sarin O CH3 F CH3 soman H3C P CH3 O P S O O parathion NO2 O P N CN tabun Pesticides: S CH3 O O S CO2Et CO2Et malathion CH3 Peptides that recognize VX Dr. Cyndi Wells, Dr. Ben Warner, Los Alamos Natl. Lab. NH2-Ser-GG-Arg-GG-His-GG-His-Phe

NH2-Arg-GG-Ser-GG-His-GG-Ser-Phe NH2-Trp-GG-His-GG-His-GG-Trp-Phe NH2-Arg-GG-Tyr-GG-Arg-GG-Ser-Phe NH2-Tyr-GG-Trp-GG-Tyr-GG-Trp-Phe NH2-His-GG-His-GG-His-GG-Arg-Phe O HO OH NH2 Ser HO NH2 Arg N H NH2 O O O NH O N HO NH2 His N H HO HO NH2 Tyr OH NH2 N H Trp Selectivity and Recognition: Peptide/metal receptors Peptide: hydrophobic/hydrophilic, shape, size Metal: functional group discrimination O

OH P HO OH phosphates from soil O S OH P H3C OH OH P HO OH methylphosphonic acid from nerve agents thiophosphates from pesticides differentiate by metal differentiate by peptide Degradation Products: O O O P H3C S VX N +H2O HS OH + P H3C OH methylphosphonic acid N mercaptoamine + HO ethanol

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