SEG/M1 transection interrupts crawling; functionally recovers

SEG/M1 transection interrupts crawling; functionally recovers

SEG/M1 transection interrupts crawling; functionally recovers Crawl-like defined as alternating elongation-contraction movements that propagate along the body anterior-to-posterior. Numbers inside bars are sample sizes Blue = untreated control

Light blue = sham surgery control Red = transected SEG/M1 transection crawl recovery information Recovery typically occurs within 5-10 days of transection. 2-4 days post-transection, leeches show very slow,

uncoordinated elongation and contraction of the body (I think we should call this rudimentary/partial crawl movements) Usually 2-3 weeks after transection crawl-like movements are qualitatively indistinguishable from crawling in sham/untreated controls (see video) One major difference! SEG/M1 transected leeches tend

not to search or do whole body bending as often when they recover their ability to crawl. These behaviors do eventually return but not until 4-8 weeks post-transection. SEG/M1 transection; crawl movements Dual ipsilateral hemi-connective

transection about M1 What if some of the descending information remains intact? Is crawling interrupted? No, leeches who receive hemi-connective transections, ipsilaterally above and below M1 continue to crawl normally. Thus, partial descending information from the brain is enough. This parallels our R3b-1 data nicely.

Blue = untreated control Light blue = sham surgery control Red = transected Crawl movements for dual ipsilateral hemi-connective transection data Days are relative to the only transection performed (day 0)

Does the terminal ganglion (TG) take over for the brain to control crawling following SEG/M1 transection?? No, severing the M21/TG connectives 2 months after SEG/M1 transection had no significant effect on crawling behavior. Light blue = sham surgery control Red = transected

The last section will explore the anterior lead ganglion idea. Is crawling interrupted in animals who recovered their ability to crawl following SEG/ M1 transection when we subsequently sever the connection between M1/M2? Crawling IS interrupted!

Remind audience that after transection #1, crawling is interrupted and recovers. Lead ganglion idea

Light blue = sham surgery control Maroon = M1/M2 transected Pink = M2/M3 transected SEG/M1 transection recovered crawling

Biting! Lead ganglion 7 backward crawl cycles

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