Rous Sarcoma Virus - WordPress.com

Rous Sarcoma Virus - WordPress.com

+ Rous Sarcoma Virus Andres Martinez Wirshig 201-00-3748 + Taxonomia Grupo: VI Familia: Retroviridae Subfamilia: Orthoretrovirinae Genus: Alpharetrovirus Especie: Rous Sarcoma Virus + Morfologa

Esferico Diametro Tiene 70 a 110 m 9392 nucleotidos Contiene 4 genes + Gentica Dos Cadenas Identicas de RNA con polaridad positiva.

Contiene Tres genes como base para la replicacion: Gag- Codifican para protenas estructurales. Pol- Codifica para la transcriptasa al reverso. Env- Codifica para las protenas de envoltura. Src- es el gen que ocasiona el sarcoma.

+ Gentica Clulas Normales: Pp60c-src (Pro-Oncogn) Clulas Infectadas: P60v-src (Oncogn) + Ciclo Replicativo

Penetracin del Virus DNA viral es sintetizado de RNA viral por transcriptasa Inverso. Transporta al Ncleo Es integrado al cromosoma hospedero por una protena llamada integrasa (Proceso Obligatorio). El DNA viral integrado sirve como molde para la

transcripcin del RNA viral. El 38s RNA y el splicing de los RNAs 28S y 21S son traducidos produciendo las protenas virales. Ensamblaje y Liberacin de los virones + Historia 1911- se descrubre el primer virus con la capacidad de inducir tumores en gallinas. 1966- Se le otorga el Premio Nobel a Peyton Rous por el

descubrimiento de Rous sarcoma. 1976- Bishop, Varmus y colaboradores logran aislar el fragmetno del genoma del virus. + Transmisin Huevo Por extraccin de Clulas infectadas: Primero se extrae el sarcoma

Luego se corta en pequeos pedazos Lo granizas con arena Luego se filtra con poros pequeos Recoges el filtrado y lo inyectas a un pollo joven Observa el sarcoma en el pollo inyectado. + Causas Por Agentes

Se pudo ver Necrosis en la autopsia en el centro del tumor Spindle Cell Sarcoma (Original) Tejido estriado, transluciente. Basados en los estudios se dice que la necrosis fue debido a una insuficiente fuente de sangre y hemorragia de vasos sanguneos delgados.

25 das despus la gallina muri por el crecimiento en la cavidad peritoneal del tumor transferido. + Manifestacin del Virus Se puede encontrar: Hgado Pulmones Spleen

Espacio Arcnido Ventrculos cerebrales + Imgenes de Rous Sarcoma en Gallinas + Propiedades Oncognicas Protena v-Src: Surgen de la interrupcin del mecanismo de control interno que normalmente previene la activacin de la protena cSrc en la ausencia de seales externas.

La Cinasa codificada por el virus (v-Src) esta activada de forma continua. Mientras que el normal (c-Src), esta usualmente desactivada hasta que se activa apropiadamente. + Artculos http://www.ncbi.nlm.nih.gov/pubmed/24808894 (2014) Membrane interaction of retroviral Gag proteins. http://www.ncbi.nlm.nih.gov/pubmed/24719425 (2014) Potential role for CA-SP in nucleating retroviral capsid

maturation http://www.ncbi.nlm.nih.gov/pubmed/24789780 (2014) Mechanistic Differences Between Nucleic Acid Chaperone Activity Of the Gag Proteins Of Rous Sarcoma Virus and Human Immunodeficiency Virus Type 1 are Attributed to the MA. + Prueba Corta Material Gentico de Rous Sarcoma: a) ssDNA+ b) dsRNA+ c) ssRNA+ d) ssDNA- El Cientfico que descubri el Virus fue: Bishop (Cierto O Falso)

El Virus Pertenece al Grupo: a) V b) VII c) VI d) IV Cuantos Nucletidos Contiene el Virus? + Referencias Microbiology: Jensen Et AL. Recuperado de http ://www.ncbi.nlm.nih.gov/pmc/articles/PMC300571/pdf/p nas00181-0066. pdf (2001). G. Martin. The Hunting of the Src. Recuperado

de http://jkweb.mcb.berkeley.edu/external/research-in-pro gress/5-3/signaling/ src_kinases.html (2014). R. Dick, V. Vogt. Membrane interaction of retroviral Gag proteins. Recuperado de http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010771/ + Referencias (1998). N. Krishna, S. Campell,V. Vogt, J. Wills. Genetic Determinants of Rous Sarcoma Virus Particle Size. Recuperado dehttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940 9/pdf/jv000564.pdf

(1992) A. Tanaka, H. Hara, H. Park, J. Wolfert, M. Fujihara, R. Izutani. Infection of terminally differenciated myotubes with Rous Sarcoma Virus (RSV): lack of integration but presence of RSV mRNA. Recuperado de http://vir.sgmjournals.org/content/73/7/1781.full.pdf + Referencias (2014). M. England, J. Purdy, I. Ropson, P. Dalessio, R. Craven. Potential role for CA-SP in nucleating retroviral capsid maturation. Recuperado de http://jvi.asm.org/content/early/2014/04/03/JVI.0030914.abstract (2014). T. Rye-Mccurdy, S. Nadaraia-Hoke, N. GudleskiORegan, J. Flanagan, L. Parent, K. Musier-Forsyth.

Mechanistic Differences Between Nucleic Acid Chaperone Activity Of the Gag Proteins Of Rous Sarcoma Virus and Human Immunodeficiency Virus Type 1 are Attributed to the MA. Recuperado de http://jvi.asm.org/content/early/2014/04/24/JVI.0073614.abstract

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