Anatomy & Physiology SIXTH EDITION Chapter 22, part

Anatomy & Physiology SIXTH EDITION Chapter 22, part

Anatomy & Physiology SIXTH EDITION Chapter 22, part 3 The Lymphatic System and Immunity PowerPoint Lecture Slide Presentation prepared by Dr. Kathleen A. Ireland, Biology Instructor, Seabury Hall, Maui, Hawaii

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Frederic H. Martini Fundamentals of SECTION 22-4 Specific Defenses Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Forms of immunity Innate immunity Genetically determined Present at birth Acquired immunity Not present at birth Achieved by exposure to antigen Active immunity

Passive immunity Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.14 Types of Immunity Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.14

Properties of immunity Specificity activated by and responds to a specific antigen Versatility is ready to confront any antigen at any time Memory remembers any antigen it has encountered Tolerance responds to foreign substances but ignores normal tissues

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings The immune system response Antigen triggers an immune response Activates T cells and B cells T cells are activated after phagocytes exposed to antigen T cells attack the antigen and stimulate B cells

Activated B cells mature and produce antibody Antibody attacks antigen Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.15 An Overview of the Immune Response Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Figure 22.15 SECTION 22-5 T cells and Cell-mediated Immunity Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Major types of T cells Cytotoxic T cells (TC) attack foreign cells

Helper T cells (TH) activate other T cells and B cells Suppressor T cells (TS) inhibit the activation of T and B cells Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Antigen presentation Antigen-glycoprotein combination appears

on a cell membrane Called MHC proteins (Major Histocompatibility Complex) Coded for by genes of the MHC T-cells sensitive to the antigen are activated upon contact Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings MHC classes

Class I found on all nucleated cells Class II found on antigen presenting cells and lymphocytes Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Lymphocytes respond to antigens bound to either class I or class II MHC proteins

Antigen recognition T cell membranes contain CD markers CD3 markers present on all T cells CD8 markers on cytotoxic and suppressor T cells CD4 markers on helper T cells Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.16 Antigens and MHC Proteins

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.16 Figure 22.16 Antigens and MHC Proteins Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.16a

Figure 22.16 Antigens and MHC Proteins Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.16b Activation of CD8 cells Responds quickly giving rise to other T cells

Cytotoxic T cells seek out and destroy abnormal cells lymphotoxin Memory TC cells function during a second exposure to antigen Suppressor T cells suppress the immune response Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Figure 22.17 Antigen Recognition and the Activation of Cytotoxic T Cells Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.17 Figure 22.17 Antigen Recognition and the Activation of Cytotoxic T Cells

PLAY Animation: Cytotoxic T Cell Activation Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.17 Activation of CD4 T cells by antigens presented on class II MHC proteins

Produces helper T cells and memory T cells Activated helper T cells Secrete lymphokines that coordinate specific and nonspecific defenses Enhance nonspecific defenses Stimulate the activity of NK cells Promote activation of B cells Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Figure 22.18 Antigen Recognition and Activation of Helper T cells PLAY Animation: Antigen Recognition and Helper T Cell Activation Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.18

Figure 22.19 A Summary of the Pathways of T Cell Activation Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.19

Recently Viewed Presentations

  • DFARS Cybersecurity Compliance Adam Austin, MSIA, CISM, Sec+

    DFARS Cybersecurity Compliance Adam Austin, MSIA, CISM, Sec+

    DoD Supply Chain Risk. DoD has (correctly) determined its supply chain is a source of unacceptable risk. Many of the notorious breaches of late were a result of a compromised contractor
  • A Tudor Menu - WordPress.com

    A Tudor Menu - WordPress.com

    Calibri Arial Plantagenet Cherokee Times New Roman Office Theme A Tudor Menu The Drinks PowerPoint Presentation The Desserts Emeles - Almond and honey cakes 1 cup breadcrumbs, 4oz ground almonds, quarter cup sugar, half tsp salt, 2 eggs, oil/fat for...
  • HP210, Feasibility Study of Energy Options for Clarkson

    HP210, Feasibility Study of Energy Options for Clarkson

    Potential for selling power to the grid to recover initial investment We contacted GRO concerning installing an array for the ERC Recommendations A large system is not economically feasible A small system may be educationally beneficial Photovoltaic Cells Conclusion In...
  • Digital Signal Processing Using MATLAB®V.4

    Digital Signal Processing Using MATLAB®V.4

    Digital Signal Processing Using MATLAB®V.4 Vinay K.Ingle John G. Proakis Northeastern University PREFACE Teaching method on SP Simple "lecture-only" Integrated "lecture-laboratory" Computer-based explanations, examples and exercises Matlab software Developed by Math Works Inc. De facto standard for numerical computation in...
  • Implementing a Transition to Less Intensive Services Policy

    Implementing a Transition to Less Intensive Services Policy

    Building strong community supports outside of mental health service delivery system is key to successful transition (Herman, 2011) ... needs for care and quality of life in Assertive Community Treatment patients: an observational study (Kortrijk et al., BMC Psychiatry, 2014)...
  • A Pearl of the Sea - Understand Islam

    A Pearl of the Sea - Understand Islam

    Existence is a Sea and the 'ulama are its Pearls A short biography of Shaykh 'Abdus-Salaam Ibn Barjass (rahimahullaah) If trust in the scholars is neglected, then to whom will the Muslims refer to in a condition of difficulty and...
  • Applied Fieldwork Enquiry

    Applied Fieldwork Enquiry

    Investigate weather changes with a passing depression (using synoptic charts) Investigate local people's perception of climate change or an extreme weather event (e.g. flood, heatwave, heavy snowfall) Investigate winds in a valley or within an urban area (which may be...
  • Lecture 2b- Planning a healthy diet/Applying dietary guidelines

    Lecture 2b- Planning a healthy diet/Applying dietary guidelines

    Title: PowerPoint Presentation Author: ed. barre Last modified by: Lenovo User Created Date: 1/3/2001 5:40:13 AM Document presentation format: On-screen Show (4:3)