Abbott Diagnostics - over of valuable contributions to

Abbott Diagnostics - over of valuable contributions to

Abbott Diagnostics - over of valuable contributions to health care. 1 SB HD NICD 29 V2 Blood donations are safer than ever Source: Nat. Med. 2000; 6:1082-1086 HP_12_5607 SB HD NICD v2.0

29 V2 2 YESTERDAY, TODAY, AND TOMORROW Agar gel diffusion technique (AGD) / Ouchterlony method Simple test to perform, but Subjective and difficult visual reading interpretation Very insensitive. In 1972 Abbott developed one of the first hepatitis surface antigen test, AUSRIA-125, beginning our history as the world leader in hepatitis diagnostics.

3 HP_12_5607 SB HD NICD v2.0 29 V2 YESTERDAY, TODAY, AND TOMORROW Accurate Diagnosis of a Changing Target has Significant Patient Impact Hemodialysis Patient

Patient with kidney transplant for 10 years Due to transplant failure on dialysis on 2003 Initial test negative, Abbott HBsAg positive Confirmed by further serology and DNA test HBV with changes in 6 amino acid positions: T115R, P120Q, S154L, E164V, Q181R, S210R Avoided potential HBV transmission Sussitz S et al., Poster at 5th Int. Symposium on Molecular Diagnostics in Laboratory Medicine, Graz, June 10-12, 2004

4 HP_12_5607 SB HD NICD v2.0 29 V2 YESTERDAY, TODAY, AND TOMORROW Abbott Diagnostics continues to enhance detection accuracy The ARCHITECT HBsAg Qualitative II assay Detects the most common HBV mutants Improved Mutant detection compared to ARCHITECT

HBsAg Qualitative ARCHITECT HBsAg Qualitative II 34-6817/R02 package insert 5 HP_12_5607 SB HD NICD v2.0 29 V2 YESTERDAY, TODAY, AND TOMORROW HCV Core Antigen enables early routine detection A window period of 30-70 days after exposure exists where specific antibodies to HCV antigens are not detected (1)

(1) Leary et al,J. Med Virol., 78:1436-1440 (2006) Schematic representation adapted from S. Muerhoff Viral Hepatitis, 2004, Miedouge et al, J. Clinical Virol., 48 (2010) 1821 & George Dawson Journal Medical Virology 79:S54-S58(2007) 1.Medici et al,J. Clin Virol. 2011. 2.Miedouge et al J. Clin Viral., 2010;48:18-21. 3.Mederacke et al,J. Clin Viral., 2009;46:210-215. 4.Moscato et al, lntervirology 2011;54:61-65. 5.Gerlich and Vockel,GHI Dec 2009. HP_12_5607 SB HD NICD v2.0 29 V2

YESTERDAY, TODAY, AND TOMORROW HP_12_5607 SB HD NICD v2.0 29 V2 YESTERDAY, TODAY, AND TOMORROW Our continued innovation to support you in achieving cost-effective, timely, and reliable clinical laboratory results to impact both individual patient management

the overall health care system 8 HP_12_5607 SB HD NICD v2.0 29 V2 9 HP_12_5607 SB HD NICD v2.0 29 V2

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