() . - (e-mail: [email protected]) 1. 1.1. 3

 ()  . - (e-mail: itlambev@mail.bg) 1. 1.1. 3

() . - (e-mail: [email protected]) 1. 1.1. 3 4 3 4 , . Tyrosine Tyrosine

Mono-iodtyrosine Mono-iodtyrosine (MIT) (MIT) Di-iodtyrosine Di-iodtyrosine (DIT) (DIT) NH2 CH2 -CH

HO COOH Tyrosine I T3 DIT + DIT Thyreoglobulin T4 NH2 CH2 -CH

HO MIT + DIT Thyreoglobulin COOH I Di-iodtyrosine I I O

HO I NH2 CH2 -CH I T4 = Thyroxine COOH Regulation of thyroid hormone

synthesis Worldwide iodine nutrition 24 h: 80 g T4 40 g T3 200 g I Plasma T4: 95% T3: 5% 99.91 99.97% - , 4

L- . , .

() . . Ca2+, Na+ + G- e (AC, PLC, PL2)

Ca2+ Na+ G-

nACh GABAA AT1, mACh , , H1H5

5-HT2 5-HT1,2,3,47 (,,) ANP

D 3 4 NA dr 1.2. t1/2 1/2

3 3 36 36 hh T4 T4 168 168 hh Myxoedema? Hashimoto 131I Facial

apearance in hypothyroidism 1.3. Jodthyrox (T4 +

1. ? (- ) 2.2.

2.2.1. o -, . 3 4. - t1/2 4 , . Carbimazole () Methimazole (thiamazole) Propylthiouracil Thiamazole - tabl. 5 mg PRC: D

: , ( ). - . 2.2.2. - , T3 & T4. 2.2.3. I (t1/2 8 ) 131

( ).

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