Munvar - OMICS International | Open Access Journals

Munvar - OMICS International | Open Access Journals

OMICS Journals are welcoming Submissions OMICS International welcomes submissions that are original and technically so as to serve both the developing world and developed countries in the best possible way. OMICS Journals are poised in excellence by publishing high quality research. OMICS International follows an Editorial Manager System peer review process and boasts of a strong and active editorial board. Editors and reviewers are experts in their field and provide anonymous, unbiased and detailed reviews of all submissions. The journal gives the options of multiple language translations for all the articles and all archived articles are available in HTML, XML, PDF and audio formats. Also, all the published articles are archived in repositories and indexing

services like DOAJ, CAS, Google Scholar, Scientific Commons, Index Copernicus, EBSCO, HINARI and GALE. For more details please visit our website: http://omicsonline.org/Submitmanuscript.php Munvar Miya Shaik Human Genome Centre School of Medical Sciences Universiti Sains Malaysia Biography Munvar Miya Shaik has Bachelor degree in Pharmacy and Medical Master degree in Medical Pharmacology. His PhD thesis was focused on Neurogenetics especially focusing on migraine genetics. He has vast experience in teaching medical pharmacology to Medical and

dental students. Currently his research is focused on Migraine genetics. He is also involved in Alzheimer's and Parkinson diseases research clusters. He has published various research articles in high impact factor journals. Currently he is located in Universiti Sains Malaysia, Kelantan, Malaysia. 3 Research interest Neurogenetics focused on Neuro-degenarative disorders

Role of microRNA as biomarker and therapeutic target in Neurodegenarative disorders Pharmacoepigenomics of Migraine Therapeutic targets from Traditional medicines to treat Neuro-degenarative disorders Epigenetics of Neuro-degenarative disorders 4 Recent publications 2014 - 2012 5

MM Shaik, NB Hassan, HL Tan, SH Gan. Validity and Reliability of the Bahasa Melayu Version of the Migraine Disability Assessment Questionnaire. Biomed Research International, Volume 2014 (2014). http://www.hindawi.com/journals/bmri/2014/435856/ [ISI Indexed] (Available in Pubmed) MM Shaik, HL Tan, SH Gan. Do folate, vitamins B6 and B12 play a role in the pathogenesis of migraine?: the role of pharmacoepigenomics. CNS & Neurological Disorders Drug Targets, 2014;13(5):828-35. [ISI Indexed] (Available in Pubmed) MM Shaik, S Ahmed, SH Gan, AM Abuzenadah, E Ahmad, S Tabrez, F Ahmad, MA Kamal. How do periodontal infections affect the progression of type 2 diabetes and Alzheimers disease? CNS & Neurological Disorders Drug Targets, 2014, 13 (3), 460-466. [ISI Indexed] (Available in Pubmed)

MM Shaik, SH Gan, MA Kamal. Epigenomic approach in understanding of Alzheimer Diseases and type 2 Diabetes. CNS & Neurological Disorders Drug Targets, 2014, 13 (2), 283-289. [ISI Indexed] (Available in Pubmed) MM Shaik. Enzymes as therapeutic agents in Alzheimers Disease (Editorial). Journal of Bimolecular Research & Therapeutics, 2014, 3:2 (Available in Google Scholar) M Rasool, A Malik, A Qazi, IA Sheikh, A Manan, MH Qazi, A Chaudhary, AM Abuzenadah, M Asif, MH Alqahtani, SH Gan, MM Shaik, MA Kamal. Current view from Alzheimers disease to type 2 diabetes mellitus. CNS & Neurological Disorders Drug Targets, 2014, 13 (3), 533-542. [ISI Indexed, IF=3.810] [ISI Indexed] (Available in Pubmed)

Recent publications 6 M Arifullah, P Vikram, KK Chiruvella, MM Shaik, I Husna. A review on Malaysian plants used for screening of Antimicrobial activity. Annual Research & Review Biology, 4(13):2088-2132, 2014. MM Shaik, NB Hassan, HL Tan, S.Bhaskar, SH Gan. Reliability and Validity of Malaysian Language Translated Version of Migraine Disability Assessment (MIDAS) Questionnaire Late Breaking Abstracts of the 2013 International Headache Congress. Cephalalgia 33(11). 970-971. [ISI Indexed] (Available in Pubmed)

H Iftikhar, I Ahmad, SH Gan, MM Shaik, N Iftikhar, MS Nawaz, MA Kamal. Quinoline derivatives: candidate drugs for a class B Gprotein coupled receptor, the Calcitonin gene related peptide receptor, a cause of migraines. CNS & Neurological Disorders Drug Targets, 2014. [ISI Indexed] (Available in Pubmed) Shaik MM, Gan SH. Rapid resolution liquid chromatography method development and validation for the simultaneous determination of homocysteine, vitamin B6, B9 and B12 in human serum. Indian Journal of Pharmacology. April 2013, 2013, 45(2), 159-167. [ISI Indexed] (Available in Pubmed) R Basri, MM Shaik, MK Alam, MBA Mondol, QD Mohammad, SH Gan. Waist to hip ratio, waist to height ratio and body mass

index predict stroke risk in a Bangladeshi population. International Medical Journal, 12/2013; 20(6):740-743. [ISI Indexed] (Available in Pubmed) Shaik MM, Loo KW, Gan SH. Burden of stroke in Nepal. International Journal of Stroke, 2012, 7(6) :517-20 [ISI Indexed] (Available in Pubmed) Pharmacoepigenomics of Migraine Over the years, many pathological theories related to migraine were published However, Migraine is not understood completely in view of Treatment Various factors, such as alcohol, smoking, nutrition, stress,

environmental changes, exercises and menstrual cycles in women, have been reported to play a role in causing migraines 7 Why ? However, the Question is Why certain precipitator cause migraine in some patients but not others ? This is still UNKNOWN 8 Genetics But there is a role of genetic vulnerability in selective

physiological alterations. This provides an opportunity to investigate the genetic basis of migraines based on previously published pathological theories of migraines due to migraines heritable nature. 9 Genetics Based on Cortical Spreading Depression and other theories Vascular Genes (Related to blood vessels) Based on Hormonal affect on Migraine Hormonal Genes

(Related to Estrogen) 10 Vascular Genes Homocysteine Higher levels of Homocysteine Vit. B6, B9 & B12 (For methylation & Conjugation of HCY) Diet 11

Highly reactive amino acid Endothelial cell injury (Research done in animals and cell lines) Nitric Oxide MTHFR Enzyme (Methylene tetrahydro folate reductase) MTHFR Gene

(Harker, Ross et al. 1976; Wall, Harlan et al. 1980); (Stamler, Osborne et al. 1993); (Cooke and Tsao 1994); (Hering-Hanit, Gadoth et al. 2001 Migraine 12 Higher levels of Homocysteine Low levels of Vitamin B6, B9 and B12

MTHFR gene defect Vitamins B for Migraine ? Lowering Homocysteine levels Intake of Vit. B6, B9 & B12 MTHFR gene defect Migraine disability 13 Estrogen & Homocysteine

14 MM Shaik, HL Tan, SH Gan. Do folate, vitamins B6 and B12 play a role in the pathogenesis of migraine?: the role of pharmacoepigenomics. CNS & Neurological Disorders Drug Targets, 2014;13(5):828-35. [ISI Indexed] (Available in Pubmed) Estrogen & Vitamins Vitamin B6 decrease the biological activities of oestrogen. Vitamins B6, B12 and folate are key cofactors of the enzymes implicated in oestrogen conjugation and methylation. Therefore, diminished concentrations of B vitamins can upset oestrogen detoxification and cause higher levels of circulating oestrogen 15 Estrogen & Homocysteine

16 MM Shaik, HL Tan, SH Gan. Do folate, vitamins B6 and B12 play a role in the pathogenesis of migraine?: the role of pharmacoepigenomics. CNS & Neurological Disorders Drug Targets, 2014;13(5):828-35. [ISI Indexed] (Available in Pubmed) Estrogen & Homocysteine 17 MM Shaik, HL Tan, SH Gan. Do folate, vitamins B6 and B12 play a role in the pathogenesis of migraine?: the role of pharmacoepigenomics. CNS & Neurological Disorders Drug Targets, 2014;13(5):828-35. [ISI Indexed] (Available in Pubmed) Hypothesis The role of epigenetics in migraine is a new, unexplored field that has

pharmacological implications. The proposed study of vitamin supplements aims to examine the reduction of homocysteine levels associated with the MTHFR C677T polymorphism in migraine patients. It would also be interesting to study the DNA methylation profiles of the promoter regions of candidate genes in migraine patients to better explain migraine occurrence. 18 SIGNATURE Munvar Miya Shaik Human Genome Centre School of Medical Sciences,

Universiti Sains Malaysia Kubang Kerian, 16150 Kelantan, Malaysia H/P: +60-10-9227448 Email: [email protected] http://scholar.google.com/citations? user=JeSDTZ0AAAAJ&hl=en JOURNALS 1.Molecular Pharmaceutics & Organic Process Research http:// esciencecentral.org/journals/molecular-pharmaceutics-organic-process-research.p hp 2. Clinical Pharmacology & Biopharmaceutics http://omicsgroup.org/journals/clinical-pharmacology-biopharmaceutics.php

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